Boneprim is a biologically active supplement that contains Calcium Bisglycinate 500 mg, which is equal to 100 mg Calcium.
Calcium is a mineral involved in a large number of vital functions. It is an important integrative component of the human body and critical for human health. It has been well established that calcium intake is helpful in the prevention and treatment of osteoporosis, which has become one of the most serious public health problems across the world. [1]
Calcium intake is usually associated with the intake of dairy products such as milk, yogurt and cheese, as they are rich sources of calcium. In the United states and in Holland, 72 and 58% of calcium supply come from dairy products, respectively, whereas in China, only around 7% of total calcium intake comes from dairy products, while most comes from vegetables (30.2%) and legumes (16.7%). Fortified foods such as cereals and juices can additionally become important sources of calcium. [2] Supplements are also a great dietary source of calcium for some populations. However, the use of supplements also varies between countries. In the United States and Canada, around 40% of the adult population was reported to have taken calcium supplements in the month before the interview, and this figure increased to 70% in the older women group. [3] On the other hand, in Argentina and in Holland, very few women reported taking calcium supplements, even during pregnancy. [4]
Calcium requirements are high during all stages of life. Dietary reference values for individuals over 19 years of age vary from 1000 mg to 1300 mg, depending on the reference guidelines. [5] During pregnancy, most guidelines acknowledge the increased demand of calcium; however, while some guidelines increase recommendations up to 1300 mg/day to achieve a positive balance, other guidelines state that metabolic adaptations during pregnancy compensate the required calcium demand [6]
Approximately 99% of total body calcium is in bone, where it provides rigidity and structure to the skeletal system and acts as a calcium reservoir. The remaining fraction participates in metabolic processes, including vascular and muscle contraction, nervous system transmission, transmembrane transport, enzymatic activation, and hormonal function. The majority of studies of long‐term consequences of inadequate calcium intake are related to bone health, especially rickets in children and fractures, osteopenia, and osteoporosis in older adults. [7]
Calcium Bisglycinate consists of calcium bound to glycine with a strong type of bond called chelation. It is bioavailable, gentle, and soluble form of calcium which is pH stable even in the acidic environment of the stomach. The stable bonds between the glycine molecules with the calcium ions prevent dissociation, and more stable compound means less interaction with dietary inhibitors, leading to greater bioavailability. The bioavailability of Calcium Bisglycinate is thought to be around 44%, which is significantly higher than other common calcium sources (for example, calcium carbonate and calcium citrate are thought to be similar at around 24%). Calcium Bisglycinate is less affected by dietary inhibitors. Dietary inhibitors, such as phytic acid, can significantly decrease the bioavailability of calcium as it can bind metal ions strongly, preventing their absorption. Because Calcium Bisglycinate is more bioavailable, a lower dose of calcium can deliver the same benefit and may be better tolerated. [8]
Since the most recent systematic review of calcium‐related health outcomes, published in 2009, was based mainly on bone health, 35 new evidence on the effect of adequate calcium intake on other health outcomes has been published. One of the most well‐documented benefits of calcium supplementation beyond bone health is a significant reduction in the risk of preeclampsia and maternal morbidity in pregnant women and preterm birth. [9]
Dietary calcium deficiency is considered to be widespread globally, with published estimates suggesting that approximately half of the world's population has inadequate access to dietary calcium. Calcium is essential for bone health, but inadequate intakes have also been linked to other health outcomes, including pregnancy complications, cancers, and cardiovascular disease. Populations in low‐ and middle‐income countries (LMICs) are at greatest risk of low calcium intakes, although many individuals in high‐income countries (HICs) also do not meet recommendations. Paradoxically, many LMICs with lower calcium intakes show lower rates of osteoporotic fracture as compared with HICs, though data are sparse. [10] 

References
[1] Li K, Wang XF, Li DY, Chen YC, Zhao LJ, Liu XG, Guo YF, Shen J, Lin X, Deng J, Zhou R, Deng HW. The good, the bad, and the ugly of calcium supplementation: a review of calcium intake on human health. Clin Interv Aging. 2018 Nov 28;13:2443-2452. doi: 10.2147/CIA.S157523. PMID: 30568435; PMCID: PMC6276611.
[2] Huang F., Wang Z., Zhang J., Du W., Su C., Jiang H., Jia X., Ouyang Y., Wang Y., Li L., et al. Dietary calcium intake and food sources among Chinese adults in CNTCS. PLoS ONE. 2018;13:e0205045. doi: 10.1371/journal.pone.0205045.
[3] Bailey R.L., Dodd K.W., Goldman J.A., Gahche J.J., Dwyer J.T., Moshfegh A.J., Sempos C.T., Picciano M.F. Estimation of Total Usual Calcium and Vitamin D Intakes in the United States. J. Nutr. 2010;140:817–822. doi: 10.3945/jn.109.118539.
[4] Cormick G., Zhang N.N., Andrade S.P., Quiroga M.J., Di Marco I., Porta A., Althabe F., Belizán J.M. Gaps between calcium recommendations to prevent pre-eclampsia and current intakes in one hospital in Argentina. BMC Res. Notes. 2014;7:920. doi: 10.1186/1756-0500-7-920.
[5] World Health Organization . Vitamin and Mineral Requirements in Human Nutrition. 2nd ed. WHO; Geneva, Switzerland: 2004.
[6] Ross A.C., Manson J.E., Abrams S.A., Aloia J.F., Brannon P.M., Clinton S.K., Durazo-Arvizu R.A., Gallagher J.C., Gallo R.L., Jones G., et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J. Clin. Endocrinol. Metab. 2011;96:53–58. doi: 10.1210/jc.2010-2704.
[7] Cormick, G. & Belizán J.M.. 2019. Calcium intake and health. Nutrients 11: E1606.
[8] Cambridge Commodities - https://www.cambridgecommodities.com/ingredients/our-brands/core-chelate-/calcium-bisglycinate.htm
[9] Gomes, F. & Ashorn P.. 2022. Calcium supplementation for the prevention of hypertensive disorders of pregnancy: current evidence and programmatic considerations. Ann. N.Y. Acad. Sci. 10.1111/nyas.14733. 
[10] Shlisky J, Mandlik R, Askari S, Abrams S, Belizan JM, Bourassa MW, Cormick G, Driller-Colangelo A, Gomes F, Khadilkar A, Owino V, Pettifor JM, Rana ZH, Roth DE, Weaver C. Calcium deficiency worldwide: prevalence of inadequate intakes and associated health outcomes. Ann N Y Acad Sci. 2022 Jun;1512(1):10-28. doi: 10.1111/nyas.14758. Epub 2022 Mar 5. PMID: 35247225; PMCID: PMC9311836.